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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 14 Documents
 1   2 
Search results for , issue "Vol 22 No 3, 2011" : 14 Documents clear
Cytotoxicity test pentacyclic triterpenes of Eupatorium inulifolium HBK on myeloma cells and their docking study Sri Mulyani Mulyadi
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.275 KB) | DOI: 10.14499/indonesianjpharm0iss0pp182-190

Abstract

A  test  of  cytotoxic  activity  of  pentacyclic  triterpenes  12,13-Dihydro-1-α-amirin-20,30-en-3-acetate and12,13-Dihydro-α-amirin-20,30-en-3ol compounds on  myeloma  cells  and  their  docking  has  been  conducted.  Two  compounds  were treated on myeloma cells which their cells densities have been determined. They were  subsequently  incubated  with  a  series  of  compound  dosage  from  2000 µg/mL  to  125  µg/mL.  This  research  aims  to  determine  the  level  in  which  both the  compounds  influence  the  myeloma  cells  using  MTT method  (reactor  3-(4,5-Dimetiltiazol-2-il)-2,5-difenil  tetrazollium  bromide)  and  their  docking  that  react to  receptor  1XKK.  Activity  of  compounds  on  myeloma  cell  after  24  hour incubation has shown that the values of IC50 for 12,13-Dihydro-α-amirin-20,30-en-3-acetate and 12,13-Dihydro-α-amirin-20,30-en-3ol are 0.428 mM and 1.515 mM, respectively. In this research, doxorubicin is used as a positive control. The IC50 value of doxorubicin is 6.896 x 10-5 µg/mL. Results show that docking score for  12,13-Dihydro-α-amirin-20,30-en-3-acetat  to  Epidermal  Growth  Factor Receptor  (1XKK)  is  -78.9662  (7).  Meanwhile,  docking score  for  12,13-Dihydro-α-amirin-20,30-en-3-ol to Epidermal Growth Factor Receptor(1XKK) is -74.1941 (10).  Doxorubicin  docking  score  is  -86.6585  (2).  From  the  results,  it  can  be inferred  that  the  two  compounds  have  cytotoxic  activities  with  bigger  IC50 than the  doxorubicin  as  positive  control.  In  order  to  obtain  more  potent  cytotoxic activity,  the  coumpound  has  to  be  modified  and  tested  and  then  docked  using receptor Epidermal Growth Factor Receptor.Keywords:cytotoxic activity; EGFR; myeloma cells; 12,13-Dihidro-α-amirin-20,30-en-3-asetat dan 12, 13-Dihidro-α-amirin-20,30-en-3-ol
Development of fast disintegrating tablet formula of ketoprofen-β-cyclodextrin inclusion complexes Rachmawati, Heni; Marbun, Estherina Juliana; Pamudji, Jessie S.
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.281 KB) | DOI: 10.14499/indonesianjpharm0iss0pp229-237

Abstract

Ketoprofen  is  one  of  non  steroidal  anti  inflammatory  drugs  (NSAID)  used for  rheumatoid  arthritis.  However,  unpleasant  taste of  ketoprofen  leads  to difficulty  in  the  formulation,  in  particular  for  oral  route.  Therefore,  in  present study, a technique to mask the unacceptable taste of ketoprofen was developed. Then,  a  fast  disintegrating  tablet  on  this  inclusion  complex  was  established  for rapid  release  and  faster  analgesic  effect  of  ketoprofen.  Taste  masking  was prepared  by  complex  inclusion  with  β-cyclodextrin.  The  ratio  of  ketoprofen  and β-cyclodextrin  was  varied.  The  fast  disintegrating  tablet  was  formulated  with direct compression using various ratios of mannitoland lactose as tablet diluent, the main factor influencing the successful of fast disintegrating tablet. Evaluation of  final  product  was  performed  according  to  compendial  standard  and  specific requirements  for  fast  disintegrating  tablet.  The  best  ratio  from  ketoprofen  and β-cyclodextrin  was  2:3  with  concentration  of  ketoprofen  in  inclusion  complex was  40.32%.  The  tablet  met  standard  requirement  was resulted  with  the composition  of  ketoprofen-cyclodextrin  equivalent  to  50  mg  of  pure  ketoprofen and mannitol and lactose (ratio 1:1) as tablet diluent. Fast disintegrating tablet of  modified  ketoprofen  in  inclusion  complex  was  fulfilled  standard  specification for ketoprofen tablet with better acceptance.Key words:ketoprofen, inclusion complex, fast disintegratingtablet, beta cyclodextrin.
The determination of quercetin in Plectranthus scutellarioides(L.) R.Br. leaves extract and its In SilicoStudy on Histamine H4 Receptor Moektiwardoyo, Moelyono; Levita, Jutti; Sidiq, Syafrudin Purnama; Ahmad, Khoziah; Mustarichie, Resmi; Subarnas, Anas; ., Supriyatna
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.578 KB) | DOI: 10.14499/indonesianjpharm0iss0pp191-196

Abstract

Plectranthus  scutellarioides  (L.)  R.Br.,  or  jawer  kotok,  Family  Lamiaceae, grows  widely  in  Indonesia,  and  has  a  long  history  of  therapeutic  usage  in Indonesian traditional jamuto cure various diseases. The brownish purple leaves of  Plecranthus  contain  alkaloids,  saponin,  flavonoids,  tannin,  volatile  oils,  and quercetin  which  has  been  proven  to  exert  antiinflammatory  activity.  In  this research,  a  determination  of  quercetin  in  Plecranthus  leaves  extract  was performed and followed by a study of its interaction with histamine H4 receptor to  understand its  anti-inflammatory  activity.  The  dry  leaves  were  macerated by using  a  mixture  of  methanol  and  water  (1:1)  for  48  hours  and  the  solvent  was evaporated  at  low  temperature  (40-50oC).  Analysis  of  quercetin  in  the  extract was performed by using reversed-phase HPLC method LC-10AT VP (Shimadzu), Atlantis  Hilicsilica  C18  (Waters®)  150  mm  x  4.6  mm,  5  µm  as  stationary  phase and  a  mixture  of  acetonitrile,  phosphoric  acid,  and methanol  (40:50:10),  flow rate 0.8 mL/minute.  In silicostudy of quercetin with histamine H4 receptor was performed by using AutoDock Tools 3.0.5. Histamine H4 receptor (H4R) belongs to  G  protein-coupled  receptors  which  is  involved  in arthritis,  asthma,  and inflammations.  The  3D  structure  model  of  H4R  was  built  by  using  MODELLER 9v7.  Quercetin  contained  in  Plecranthus  leaves  extract  was  0.05  %.  This compound interacted with H4R viahydrogen bond formation with Lys158 (2.006 Å)  and  Glu182  (2.048  Å),  and  van  der  Waals  interaction  with  Trp90,  Leu91, Asp94, Tyr95, Phe168, Thr178, Ser179, Tyr319, Phe344, and Tyr340, therefore Plecranthus  leaves  extract  might  have  a  chance  to  be  used  as  histamine  H4 receptor inhibitor.Key  words  :   histamine  H4  receptor,  in  silico  study,  Plecranthus  leaves,  Plectranthus scutellarioides, quercetin
Effect of the combination of curcuminoid and essential oil on the serum ureum and creatinine level of patientswith osteoarthritis Kertia, Nyoman; ., Danang
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.741 KB) | DOI: 10.14499/indonesianjpharm0iss0pp151-157

Abstract

The curcuminoid of Curcuma domesticaVal. rhizome and the essential oil of Curcuma xanthorrhizaRoxb. rhizome can be used for rheumatic treatment,but no enough  data  regarding  those  side  effects.   This  study  aimed  to  determine  the efect  of  curcuminoid  of  Curcuma  domestica Val.  combined  with  essential  oil  from Curcuma  xanthorriza Roxb.  to  the  serum  ureum  and  creatinine  level  of  patients with osteoarthritis. This treatment was compared tothat of piroxicam. This was a Prospective  Randomized  Open  end  Blinded  Evaluation  (PROBE),  involving  38 patients with knee osteoarthritis.The treatment group were given the combination of  15  mg  curcuminoid  of  Curcuma  domestica Val.  and  100  mg  essential  oil  of Curcuma xanthorrhizatwice daily for two weeks. The control group were given 10 mg piroxicam twice daily for two weeks. In the treatment group the serum ureum level  decreased  4.58±6.20%  mg,  while  in  the  control group  the  ureum  level increased  1.68±8.24%  mg.  In  the  treatment  group  the serum  creatinine  level decreased  0.12±0.36%  mg,  while  in  the  control  group the  creatinine  level increased  0.18±0.29%  mg.  Decreasing  of  serum  ureum  level  in  the  treatment group was significantly different compared to increasing of that level in the control group  (p<0.01).  Decreasing  of  the  creatinine  level  in  the  teatment  group  was significantly  different  compared  to  increasing  of  that  level  in  the  control  group (p<0.01).Key words: Curcuminoid, Essential Oil, Ureum, Creatinine, Osteoarthritis

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